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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
9.39
Human Site:
S753
Identified Species:
14.76
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S753
F
L
N
G
T
N
G
S
T
E
G
T
L
L
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
S753
F
L
N
G
T
N
G
S
T
E
G
T
L
L
E
Dog
Lupus familis
XP_531814
1283
145094
I727
L
M
V
V
P
D
K
I
S
D
V
A
D
L
L
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
E752
N
G
T
N
G
S
T
E
G
N
L
L
E
R
L
Rat
Rattus norvegicus
XP_002726765
1361
151628
E755
N
G
T
N
G
S
T
E
G
T
L
L
E
R
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
T859
L
Q
N
G
T
N
G
T
T
E
G
T
L
L
E
Frog
Xenopus laevis
NP_001089247
1340
149481
G732
I
L
Q
N
G
T
N
G
S
T
E
G
T
L
L
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
T752
E
I
L
Q
N
S
S
T
G
G
P
E
G
T
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
V648
M
P
T
E
L
Q
E
V
R
A
L
L
A
P
M
Honey Bee
Apis mellifera
XP_392346
1120
127429
I578
P
S
C
R
K
D
V
I
I
E
R
Q
E
A
I
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
M644
S
P
D
A
S
S
F
M
T
T
A
T
A
T
L
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
C725
G
L
T
P
K
D
G
C
E
M
A
L
S
A
L
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
E734
A
R
I
F
S
T
S
E
A
N
G
R
N
A
N
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
N726
G
T
L
Y
A
Q
L
N
Q
C
I
T
A
S
G
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
E700
F
S
K
L
P
D
L
E
R
M
L
A
R
I
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
6.6
N.A.
0
0
N.A.
N.A.
80
13.3
0
N.A.
0
6.6
13.3
13.3
P-Site Similarity:
100
N.A.
100
33.3
N.A.
6.6
6.6
N.A.
N.A.
86.6
20
20
N.A.
0
13.3
33.3
20
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
7
7
0
0
0
7
7
14
14
20
20
0
% A
% Cys:
0
0
7
0
0
0
0
7
0
7
0
0
0
0
0
% C
% Asp:
0
0
7
0
0
27
0
0
0
7
0
0
7
0
0
% D
% Glu:
7
0
0
7
0
0
7
27
7
27
7
7
20
0
20
% E
% Phe:
20
0
0
7
0
0
7
0
0
0
0
0
0
0
0
% F
% Gly:
14
14
0
20
20
0
27
7
20
7
27
7
7
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
7
7
7
0
0
0
0
14
7
0
7
0
0
7
7
% I
% Lys:
0
0
7
0
14
0
7
0
0
0
0
0
0
0
0
% K
% Leu:
14
27
14
7
7
0
14
0
0
0
27
27
20
34
47
% L
% Met:
7
7
0
0
0
0
0
7
0
14
0
0
0
0
7
% M
% Asn:
14
0
20
20
7
20
7
7
0
14
0
0
7
0
7
% N
% Pro:
7
14
0
7
14
0
0
0
0
0
7
0
0
7
0
% P
% Gln:
0
7
7
7
0
14
0
0
7
0
0
7
0
0
0
% Q
% Arg:
0
7
0
7
0
0
0
0
14
0
7
7
7
14
0
% R
% Ser:
7
14
0
0
14
27
14
14
14
0
0
0
7
7
0
% S
% Thr:
0
7
27
0
20
14
14
14
27
20
0
34
7
14
0
% T
% Val:
0
0
7
7
0
0
7
7
0
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _